
1.WHAT SCIENTIST DO ?
Researchers Have Developed An AI System That Can Create Artificial Enzymes From Scratch. In Laboratory Experiments, Some Of These Enzymes Showed Activity Comparable To The Natural Enzymes, Even Though The Artificially Produced Amino Acid Sequences Differed Significantly From The Known Natural Proteins.
2.HOW SCIENTISTS CREATE IT?
TO CREATE THE MODEL, SCIENTISTS FED THE AMINO ACID SEQUENCES OF 280 MILLION DIFFERENT PROTEINS OF ALL KINDS INTO A MACHINE LEARNING MODEL AND LET IT PROCESS THAT INFORMATION FOR WEEKS. WE THEN REFINED THE MODEL BY PRIMING IT WITH 56,000 SEQUENCES FROM FIVE LYSOZYME FAMILIES AND SOME CONTEXTUAL INFORMATION ABOUT THESE PROTEINS.
3.WHY SCIENTISTS APPRECIATE AI?
Training Sequence-based Models With Large Amounts Of Data Makes Structure And Rule Learning Very Powerful. Learn Which Words Appear Together And Composition. The Ability To Create Functional Proteins From Scratch Marks A New Era In Protein Design. This Is A Versatile New Tool Available To Protein Engineers, And Is Expected To Have Therapeutic Applications.
With Proteins, The Design Possibilities Were Almost Limitless. Lysozyme Is Small Like A Protein, Consisting Of Up To About 300 Amino Acids. But Since There Are 20 Possible Amino Acids, There Are A Huge Number (20,300) Of Possible Combinations. This Is More Than All Human Beings Who Have Ever Lived Multiplied By The Number Of Grains Of Sand On Earth Multiplied By The Number Of Atoms In The Universe.